Genomic imprinting mechanisms in embryonic and extraembryonic mouse tissues
نویسندگان
چکیده
منابع مشابه
Mechanisms of genomic imprinting.
Imprinted genes represent a curious defiance of normal Mendelian genetics. Mammals inherit two complete sets of chromosomes, one from the mother and one from the father, and most autosomal genes will be expressed from both the maternal and the paternal alleles. Imprinted genes, however, are expressed from only one chromosome, in a parent-of-origin-dependent manner. Because silent and active pro...
متن کاملPolyploidization of extraembryonic tissues during mouse embryogenesis.
It has recently been shown that visceral yolk-sac endoderm is derived from the primitive endoderm of the 4.5-day mouse blastocyst (Gardner & Papaioannou, 1975; Gardner & Rossant, 1979). During development, primitive endodermal cells acquire nuclei with more than four times the haploid amount of DNA. The finding of metaphases with multiple sets of chromosomes suggests that the diploid precursors...
متن کاملGenomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues.
K Nakabayashi, S Makino*, S Minagawa* , A C Smith, J S Bamforth, P Stanier, M Preece, L Parker-Katiraee, T Paton, M Oshimura, P Mill, Y Yoshikawa`, C C Hui, D Monk, G E Moore, S W Scherer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
متن کاملStatus of genomic imprinting in mouse spermatids.
The advent of human round spermatid microinjection (ROSI) into oocytes as a treatment for severe male infertility raises the question of whether spermatids have undergone all of the maturation processes necessary for normal development. It is particularly important to know whether spermatids have undergone correct genomic imprinting, which results in the parent-of-origin-specific expression of ...
متن کاملGenomic Imprinting Variations in the Mouse Type 3 Deiodinase Gene Between Tissues and Brain Regions
The Dio3 gene, which encodes for the type 3 deiodinase (D3), controls thyroid hormone (TH) availability. The lack of D3 in mice results in tissue overexposure to TH and a broad neuroendocrine phenotype. Dio3 is an imprinted gene, preferentially expressed from the paternally inherited allele in the mouse fetus. However, heterozygous mice with paternal inheritance of the inactivating Dio3 mutatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heredity
سال: 2010
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.2010.23